Toxic Epidermal Necrolysis

Diseases

Arthritis
Asthma
Backpain
Diabetes
Heart Attack
High Blood Pressure
Headache
Migraine
Depression
Disorders

General Ailments
Blood Disorders
Digestive Disorders
Gastroenterology Disorders
Respiratory Disorders
Fevers
Gynacological Conditions
Cardiology Diseases
Neurology Diseases
Cardiovascular Diseases
Medication

Medication Library: Information listing all medication & drugs in Albhabatical Order. Learn More..
Mental Health

Your complete mental health care guide, all information on metal disorders. Learn More..
Home Remedies

Treatment and Cure of all ailments and health disorders by natural homemade remedies by experts. Learn More..
Health Articles

Health & Executive
Life & Health
Health & Happiness
Heart Health
Lung Health
Dental Health
Eye Care
Stress & Strain
Your Health Diet
Fitness & Exercise
Planning For Well-Being

 

Home :: Diseases :: Toxic Epidermal Necrolysis
 

Toxic Epidermal Necrolysis

What is Toxic Epidermal Necrolysis

Toxic epidermal necrolysis is the most severe adverse drug reaction. A possible relationship with medications can be established in almost 90% of patients with TEN. Toxic Epidermal Necrolysis, like SJS, features extensive mucosal involvement in over 90% of patients. Unlike SJS, however, the degree of epidermal detachment is over 30% of the TBSA .

Toxic Epidermal Necrolysis has a significant morbidity, and a mortality rate of about 30%. Most deaths are attributed to sepsis.

Symptoms of Toxic Epidermal Necrolysis

Constitutional symptoms such as fever and malaise are often present in Toxic Epidermal Necrolysis. The eruption typically starts on the face and the upper torso and extends rapidly. Individual lesions include flat, atypical targets with dusky centers and purpuric macules. Flaccid blisters also may form. Oral, ocular, genitourinary, respiratory, and gastrointestinal mucosa all may be involved, and therefore require appropriate evaluation. Nearly 69% of patients have ocular manifestations ranging from mild conjunctivitis to corneal ulcerations.

Clinicians familiar with Toxic Epidermal Necrolysis usually have little difficulty recognizing a fully developed case. A skin biopsy, and in some cases a direct immunofluorescence study, can help confirm a diagnosis of SJS and exclude other diagnostic considerations.

Treatment of Toxic Epidermal Necrolysis

Therapy for TEN is supportive. Corticosteroid use therapy showed no benefit in the treatment of patients with TEN. Patients with Toxic Epidermal Necrolysis need aggressive fluid and electrolyte correction, local skin care, and fastidious infection precautions. This is best achieved in a burn unit.

Intravenous immune globulin, cyclosporine, and cyclophosphamide have been reported to improve outcomes in Toxic Epidermal Necrolysis. These results are based on small series of patients, and at the present time, the use of these agents in Toxic Epidermal Necrolysis is not universally accepted.

Health Home Health Blog Health Resources Policy & Terms Advertise With Us Contact Us

Your feedback and queries are greatly appreciated, keep them coming here..
© www.diseasesatoz.com All Rights Reserved.


Disclaimer: All information on www.diseasesatoz.com is for educational purposes only. It is not a substitute for professional medical advice. For specific medical advice, diagnoses, and treatment, please consult your doctor.